/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

BROWSE
Latest Articles
Most accessed
thematic issues
volumes
authors

BROWSE

Latest Articles Most Accessed Thematic Issues Volumes Authors

Author

2 article(s) from Kelter, Gerhard

Total synthesis and cytotoxicity of the marine natural product malevamide D and a photoreactive analog

Werner Telle,
Gerhard Kelter,
Heinz-Herbert Fiebig,
Peter G. Jones and
Thomas Lindel

Beilstein J. Org. Chem. 2014, 10, 316–322, doi:10.3762/bjoc.10.29

PDF

Graphical Abstract

Figure 1: Structures of the strongly cytotoxic marine natural products malevamide D (1), isodolastatin H (2),...

Jump to Figure 1

Scheme 1: Total synthesis of malevamide D (1). a) DMSO (16 equiv), NEt₃ (5 equiv), pyridine·SO₃ (5 equiv), 0 ...

Jump to Scheme 1

Scheme 2: Formation of oxazolylphosphate 18 on attempted DEPC-mediated coupling of dipeptide 15.

Jump to Scheme 2

Scheme 3: Synthesis of tosyloximes (Z)-22 and (E)-22, X-ray structure of (E)-22. a) NH₂OH·HCl (1.5 equiv), py...

Jump to Scheme 3

Scheme 4: Synthesis of photo malevamide D 30. a) NH₃(l), t-BuOMe, −40 °C, 2 h, rt, 16 h, quant. b) I₂ (1.2 eq...

Jump to Scheme 4

Figure 2: DSC curve of diazirine 25, heating rate 5 °C/min.

Jump to Figure 2

Album

Supp Info

Full Research Paper

Published 03 Feb 2014

Full text

Synthesis and characterization of novel bioactive 1,2,4-oxadiazole natural product analogs bearing the N-phenylmaleimide and N-phenylsuccinimide moieties

Catalin V. Maftei,
Elena Fodor,
Peter G. Jones,
M. Heiko Franz,
Gerhard Kelter,
Heiner Fiebig and
Ion Neda

Beilstein J. Org. Chem. 2013, 9, 2202–2215, doi:10.3762/bjoc.9.259

PDF

Graphical Abstract

Figure 1: Natural products having a 1,2,4-oxadiazole core.

Jump to Figure 1

Figure 2: Examples of 1,2,4-oxadiazole antitumorals.

Jump to Figure 2

Scheme 1: Common synthetic strategies toward 1,2,4-oxadiazoles; (a) amidoxime route; (b) 1,3 dipolar cycloadd...

Jump to Scheme 1

Scheme 2: One-pot synthesis of 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)aniline (1) by using the amidoxime route....

Jump to Scheme 2

Figure 3: Molecular structure of 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)aniline (1). Atoms are drawn as 50% the...

Jump to Figure 3

Figure 4: Packing diagram of compound 1. Hydrogen bonds are indicated as dashed lines.

Jump to Figure 4

Scheme 3: One-pot synthesis of 4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)aniline (1) by using the 1,3-dipolar cycl...

Jump to Scheme 3

Figure 5: Molecular structure of 3-tert-butyl-5-(4-nitrophenyl)-1,2,4-oxadiazole (2). Atoms are drawn as 50% ...

Jump to Figure 5

Figure 6: Packing diagram of compound (2) showing C–H···O interactions.

Jump to Figure 6

Scheme 4: Synthesis of 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)pyrrolidine-2,5-dione (4).

Jump to Scheme 4

Figure 7: Molecular structure of 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)pyrrolidine-2,5-dione (4). At...

Jump to Figure 7

Figure 8: Molecular structure of 4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4 oxobutanoate (5). Ato...

Jump to Figure 8

Figure 9: Packing diagram of compound (5). Dashed lines indicate hydrogen bonds.

Jump to Figure 9

Scheme 5: Synthesis of 1-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenyl)-1H-pyrrole-2,5-dione (7).

Jump to Scheme 5

Figure 10: Molecular structure of (Z)-4-(4-(3-tert-butyl-1,2,4-oxadiazol-5-yl)phenylamino)-4-oxobut-2-enoic ac...

Jump to Figure 10

Figure 11: Packing diagram of compound 6. Dashed lines indicate hydrogen bonds.

Jump to Figure 11

Figure 12: In vitro antitumor activity of compounds 1, 3–7 toward 11 human tumor cell lines.

Jump to Figure 12

Figure 13: Individual IC₅₀ values [µM] of compounds 1, 3–7 in a panel of 11 human tumor cell lines.

Jump to Figure 13

Album

Full Research Paper

Published 25 Oct 2013

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / Alerts / Privacy Policy / Terms & Conditions / Impressum